被撤回的出版物: Switching of chromatin-remodelling complexes for oestrogen receptor-α (Retracted Article)

The female sex steroid hormone oestrogen stimulates both cell proliferation and cell differentiation in target tissues. These biological actions are mediated primarily through nuclear oestrogen receptors (ERs). The ligand-dependent transactivation of ERs requires several nuclear co-regulator complexes; however, the cell-cycle-dependent associations of these complexes are poorly understood. By using a synchronization system, we found that the transactivation function of ER alpha at G2/M was lowered. Biochemical approaches showed that ER alpha associated with two discrete classes of ATP-dependent chromatin-remodelling complex in a cell-cycle-dependent manner. The components of the NuRD-type complex were identified as G2/M-phase-specific ER alpha co-repressors. Thus, our results indicate that the transactivation function of ER alpha is cell-cycle dependent and is coupled with a cell-cycle-dependent association of chromatin-remodelling complexes.