Journal
EMBO MOLECULAR MEDICINE
Volume 10, Issue 10, Pages -Publisher
WILEY
DOI: 10.15252/emmm.201809024
Keywords
inflammation; miR-223; neutrophil; skin wound healing; Staphylococcus aureus
Categories
Funding
- Japan Society for the Promotion of Science [20890258, 21689049, 24689069, 23650484, 25560055, 26670773, 16H05493, 15H00601, 26861503, 16K20361]
- Takeda Science Foundation
- Uehara Memorial Foundation
- Nakatomi Foundation
- Wellcome Trust [097791/Z/11/Z]
- Royal Society
- Grants-in-Aid for Scientific Research [25560055, 23650484, 21689049, 26670773, 20890258, 26861503, 15H00601, 24689069, 16K20361, 16H05493] Funding Source: KAKEN
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Argonaute 2 bound mature microRNA (Ago2-miRNA) complexes are key regulators of the wound inflammatory response and function in the translational processing of target mRNAs. In this study, we identified four wound inflammation-related Ago2-miRNAs (miR-139-5p, miR-142-3p, miR-142-5p, and miR-223) and show that miR-223 is critical for infection control. miR-223(Y/-) mice exhibited delayed sterile healing with prolonged neutrophil activation and interleukin-6 expression, and markedly improved repair of Staphylococcus aureus-infected wounds. We also showed that the expression of miR-223 was regulated by CCAAT/enhancer binding protein alpha in human neutrophils after exposure to S. aureus peptides. Treatment with miR-223(Y/-)-derived neutrophils, or miR-223 antisense oligodeoxynucleotides in S. aureus-infected wild-type wounds markedly improved the healing of these otherwise chronic, slow healing wounds. This study reveals how miR-223 regulates the bactericidal capacity of neutrophils at wound sites and indicates that targeting miR-223 might be of therapeutic benefit for infected wounds in the clinic.
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