Journal
EMBO MOLECULAR MEDICINE
Volume 5, Issue 5, Pages 661-674Publisher
WILEY
DOI: 10.1002/emmm.201202382
Keywords
apoptosis; efferocytosis; macrophage reprogramming; pro-resolving drugs; tissue homeostasis
Categories
Funding
- NWO (VIDI) [91712303]
- DFG [SO876/3-1, SO876/6-1, FOR809, SFB914 TPB08]
- German-Israeli Foundation
- Else Kroner Fresenius Stiftung
- Wellcome Trust [086867/Z/08]
- Arthritis Research UK
- British Heart Foundation [PG/09/060, PG/11/48/28981]
- Medical Research Council
- British Heart Foundation [PG/11/48/28981] Funding Source: researchfish
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Resolution of inflammation is a coordinated and active process aimed at restoration of tissue integrity and function. This review integrates the key molecular and cellular mechanisms of resolution. We describe how abrogation of chemokine signalling blocks continued neutrophil tissue infiltration and how apoptotic neutrophils attract monocytes and macrophages to induce their clearance. Uptake of apoptotic neutrophils by macrophages reprograms macrophages towards a resolving phenotype, a key event to restore tissue homeostasis. Finally, we highlight the therapeutic potential that derives from understanding the mechanisms of resolution.
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