Journal
EMBO MOLECULAR MEDICINE
Volume 5, Issue 4, Pages 509-515Publisher
WILEY
DOI: 10.1002/emmm.201202413
Keywords
cattle; mecC; MRSA; sheep; zoonosis
Categories
Funding
- Medical Research Council (MRC) [G1001787/1]
- School of Clinical Medicine, University of Cambridge
- Moredun Research Institute
- Wellcome Trust
- NIHR Cambridge Biomedical Research Center
- MRC [G1001787] Funding Source: UKRI
- Medical Research Council [G1001787] Funding Source: researchfish
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Several methicillin-resistant Staphylococcus aureus (MRSA) lineages that carry a novel mecA homologue (mecC) have recently been described in livestock and humans. In Denmark, two independent human cases of mecC-MRSA infection have been linked to a livestock reservoir. We investigated the molecular epidemiology of the associated MRSA isolates using whole genome sequencing (WGS). Single nucleotide polymorphisms (SNP) were defined and compared to a reference genome to place the isolates into a phylogenetic context. Phylogenetic analysis revealed two distinct farm-specific clusters comprising isolates from the human case and their own livestock, whereas human and animal isolates from the same farm only differed by a small number of SNPs, which supports the likelihood of zoonotic transmission. Further analyses identified a number of genes and mutations that may be associated with host interaction and virulence. This study demonstrates that mecC-MRSA ST130 isolates are capable of transmission between animals and humans, and underscores the potential of WGS in epidemiological investigations and source tracking of bacterial infections. See accompanying article http://dx.doi.org/10.1002/emmm.201302622
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