Journal
EMBO MOLECULAR MEDICINE
Volume 5, Issue 6, Pages 805-813Publisher
WILEY
DOI: 10.1002/emmm.201201678
Keywords
Candida albicans; primary immunodeficiencies; interferon gamma; interleukin-17; disease susceptibility
Categories
Funding
- ERC [ERC-310372]
- NWO
Ask authors/readers for more resources
Candida spp. are medically important fungi causing severe mucosal and life-threatening invasive infections, especially in immunocompromised hosts. However, not all individuals at risk develop Candida infections, and it is believed that genetic variation plays an important role in host susceptibility. On the one hand, severe fungal infections are associated with monogenic primary immunodeficiencies such as defects in STAT1, STAT3 or CARD9, recently discovered as novel clinical entities. On the other hand, more common polymorphisms in genes of the immune system have also been associated with fungal infections such as recurrent vulvovaginal candidiasis and candidemia. The discovery of the genetic susceptibility to Candida infections can lead to a better understanding of the pathogenesis of the disease, as well as to the design of novel immunotherapeutic strategies. This review is part of the review series on host-pathogen interactions. See more reviews from this series.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available