Related references
Note: Only part of the references are listed.APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant
Robert Tamayev et al.
EMBO JOURNAL (2011)
Maturation of BRI2 generates a specific inhibitor that reduces APP processing at the plasma memebrane and in endocytic vesicles
Shuji Matsuda et al.
NEUROBIOLOGY OF AGING (2011)
TARGETING AMYLOID PRECURSOR PROTEIN SECRETASES: ALZHEIMER'S DISEASE AND BEYOND
J. Kelly Ganjei
DRUG NEWS & PERSPECTIVES (2010)
BACE1 Deficiency Causes Altered Neuronal Activity and Neurodegeneration
Xiangyou Hu et al.
JOURNAL OF NEUROSCIENCE (2010)
Memory Deficits Due to Familial British Dementia BRI2 Mutation Are Caused by Loss of BRI2 Function Rather than Amyloidosis
Robert Tamayev et al.
JOURNAL OF NEUROSCIENCE (2010)
The benefits and limitations of animal models for translational research in neurodegenerative diseases
Mathias Jucker
NATURE MEDICINE (2010)
The secretases: enzymes with therapeutic potential in Alzheimer disease
Bart De Strooper et al.
NATURE REVIEWS NEUROLOGY (2010)
The Genetics of Alzheimer Disease: Back to the Future
Lars Bertram et al.
NEURON (2010)
Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits
Robert Tamayev et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Presenilins are essential for regulating neurotransmitter release
Chen Zhang et al.
NATURE (2009)
APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
Anatoly Nikolaev et al.
NATURE (2009)
Generation and Initial Characterization of FDD Knock In Mice
Luca Giliberto et al.
PLOS ONE (2009)
BRI2 inhibits amyloid β-peptide precursor protein processing by interfering with the docking of secretases to the substrate
Shuji Matsuda et al.
JOURNAL OF NEUROSCIENCE (2008)
Picomolar Amyloid-β Positively Modulates Synaptic Plasticity and Memory in Hippocampus
Daniela Puzzo et al.
JOURNAL OF NEUROSCIENCE (2008)
BACE1 regulates voltage-gated sodium channels and neuronal activity
Doo Yeon Kim et al.
NATURE CELL BIOLOGY (2007)
Loss-of-function presenilin mutations in Alzheimer disease - Talking Point on the role of presenilin mutations in Alzheimer disease
Bart De Strooper
EMBO REPORTS (2007)
The presenilin hypothesis of Alzheimer's disease: Evidence for a loss-of-function pathogenic mechanism
Jie Shen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Bace1 modulates myelination in the central and peripheral nervous system
Xiangyou Hu et al.
NATURE NEUROSCIENCE (2006)
Control of peripheral nerve myelination by the β-secretase BACE1
Michael Willem et al.
SCIENCE (2006)
Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study 'recognition memory'
Rick A. Bevins et al.
NATURE PROTOCOLS (2006)
BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid β (Aβ) production
A Fotinopoulou et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
The familial dementia BRI2 gene binds the Alzheimer gene amyloid-β precursor protein and inhibits amyloid-β production
S Matsuda et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Molecular biology and genetics of Alzheimer's disease
PH St George-Hyslop et al.
COMPTES RENDUS BIOLOGIES (2005)
Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration
CA Saura et al.
NEURON (2004)
Platelet-derived growth factor induces the β-γ-secretase-mediated cleavage of Alzheimer's amyloid precursor protein through a Src-Rac-dependent pathway
D Gianni et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Medicine - The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
J Hardy et al.
SCIENCE (2002)
Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's β-amyloid precursor protein (APP)
MH Scheinfeld et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
A decamer duplication in the 3′ region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred
R Vidal et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)