Journal
EMBO MOLECULAR MEDICINE
Volume 3, Issue 12, Pages 742-754Publisher
WILEY
DOI: 10.1002/emmm.201100177
Keywords
diabetes; hippocampus; insulin; neural stem cell; olfactory bulb
Categories
Funding
- AIST
- Suzuken memorial foundation
- Foundation for Nara Institute of Science and Technology
- Grants-in-Aid for Scientific Research [21241048, 22700385, 22770204, 23123515] Funding Source: KAKEN
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In the present study, we demonstrated that insulin is produced not only in the mammalian pancreas but also in adult neuronal cells derived from the hippocampus and olfactory bulb (OB). Paracrine Wnt3 plays an essential role in promoting the active expression of insulin in both hippocampal and OB-derived neural stem cells. Our analysis indicated that the balance between Wnt3, which triggers the expression of insulin via NeuroD1, and IGFBP-4, which inhibits the original Wnt3 action, is regulated depending on diabetic (DB) status. We also show that adult neural progenitors derived from DB animals retain the ability to give rise to insulin-producing cells and that grafting neuronal progenitors into the pancreas of DB animals reduces glucose levels. This study provides an example of a simple and direct use of adult stem cells from one organ to another, without introducing additional inductive genes.
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