Journal
EMBO MOLECULAR MEDICINE
Volume 3, Issue 4, Pages 201-207Publisher
WILEY-BLACKWELL
DOI: 10.1002/emmm.201100129
Keywords
autoimmunity; ankylosing; spondylitis haematology; therapeutics; transplantation
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Funding
- Molecular and Cell Biology program RAS, Rosnauka [02.512.12.2053]
- RFBR [10-04-01771-a]
- Basic Research for Medicine RAS
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Autologous haematopoietic stem cell transplantation is highly efficient for the treatment of systemic autoimmune diseases, but its consequences for the immune system remain poorly understood. Here, we describe an optimized RNA-based technology for unbiased amplification of T cell receptor beta-chain libraries and use it to perform the first detailed, quantitative tracking of T cell clones during 10 months after transplantation. We show that multiple clones survive the procedure, contribute to the immune response to activated infections, and form a new skewed and stable T cell receptor repertoire.
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