Journal
EMBO MOLECULAR MEDICINE
Volume 1, Issue 6-7, Pages 303-314Publisher
WILEY
DOI: 10.1002/emmm.200900043
Keywords
inflammation; epithelial-mesenchymal transition; TGF-beta; TNF-alpha; NF-kappa B
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Funding
- Spanish Ministry of Education and Science [SAF2007-63893, BFU2008-01042]
- Instituto Carlos III
- Junta de Castilla y Leon
- Generalitat Valenciana
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Recent advances in our understanding of the molecular pathways that govern the association of inflammation with organ fibrosis and cancer point to the epithelial to mesenchymal transition (EMT) as the common link in the progression of these devastating diseases. The EMT is a crucial process in the development of different tissues in the embryo and its reactivation in the adult may be regarded as a physiological attempt to control inflammatory responses and to 'heal' damaged tissue. However, in pathological contexts such as in tumours or during the development of organ fibrosis, this healing response adopts a sinister nature, steering these diseases towards metastasis and organ failure. Importantly, the chronic inflammatory microenvironment common to fibrotic and cancer cells emerges as a decisive factor in the induction of the pathological EMT.
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