Journal
EMBO MOLECULAR MEDICINE
Volume 1, Issue 5, Pages 260-267Publisher
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1002/emmm.200900033
Keywords
NFATc1; Myc; EGF receptor; beta-catenin; Lrig1
Categories
Funding
- Cancer Research UK
- Wellcome Trust
- Medical Research Council
- European Union
- Cambridge University
- Hutchison Whampoa
- MRC [G0800784] Funding Source: UKRI
- Medical Research Council [G0800784, G0800784B] Funding Source: researchfish
Ask authors/readers for more resources
Mammalian epidermis is maintained by self-renewal of stem cells and terminal differentiation of their progeny. New data reveal a diversity amongst stem cells that was previously unrecognized. Different stem cell populations have different locations and differ in whether they are quiescent or actively cycling. During normal epidermal homeostasis, each stem cell population feeds a restricted number of differentiated lineages. However, in response to injury or genetic manipulation the different pools of stem cells demonstrate multi-lineage differentiation ability. While it is well established that Wnt signalling promotes hair follicle (HF) differentiation, new observations suggest a role for EGF receptor signalling in promoting differentiation of interfollicular epidermis. NFATc1 maintains quiescence in the HF, while Lrig1 exerts the same function in the junctional zone. The stage is now set for exploring the relationship between the different epidermal stem cell populations and between quiescence and lineage selection.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available