Journal
EMBO JOURNAL
Volume 32, Issue 6, Pages 886-898Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/emboj.2013.23
Keywords
import; mitochondria; presequence; TIM23 complex
Categories
Funding
- Deutsche Forschungsgemeinschaft [SFB860]
- Gottingen Graduate School for Neurosciences and Molecular Biosciences
- Max-Planck-Society
- FOR [1086/2, SCHW 823/2-1, SR7000DC]
- DFG [GSC 226/1]
- Boehringer Ingelheim Fonds
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The mitochondrial presequence translocase interacts with presequence-containing precursors at the intermembrane space (IMS) side of the inner membrane to mediate their translocation into the matrix. Little is known as too how these matrix-targeting signals activate the translocase in order to initiate precursor transport. Therefore, we analysed how signal recognition by the presequence translocase initiates reorganization among Tim-proteins during import. Our analyses revealed that the presequence receptor Tim50 interacts with Tim21 in a signal-sensitive manner in a process that involves the IMS-domain of the Tim23 channel. The signal-driven release of Tim21 from Tim50 promotes recruitment of Pam17 and thus triggers formation of the motor-associated form of the TIM23 complex required for matrix transport. The EMBO Journal (2013) 32, 886-898. doi:10.1038/emboj.2013.23; Published online 12 February 2013
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