Journal
EMBO JOURNAL
Volume 33, Issue 1, Pages 62-75Publisher
WILEY-BLACKWELL
DOI: 10.1002/embj.201284303
Keywords
DAMP; MAMP; pattern recognition receptor; PEPR; systemic immunity
Categories
Funding
- Max Planck Society [SFB670]
- MEXT of Japan [20380027]
- International Max Planck Research School Program
- Japan Society for the Promotion of Science [10J03196]
- Grants-in-Aid for Scientific Research [10J03196, 20380027] Funding Source: KAKEN
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Recognition of microbial challenges leads to enhanced immunity at both the local and systemic levels. In Arabidopsis, EFR and PEPR1/PEPR2 act as the receptor for the bacterial elongation factor EF-Tu (elf18 epitope) and for the endogenous PROPEP-derived Pep epitopes, respectively. The PEPR pathway has been described to mediate defence signalling following microbial recognition. Here we show that PROPEP2/PROPEP3 induction upon pathogen challenges is robust against jasmonate, salicylate, or ethylene dysfunction. Comparative transcriptome profiling between Pep2- and elf18-treated plants points to co-activation of otherwise antagonistic jasmonate-and salicylate-mediated immune branches as a key output of PEPR signalling. Accordingly, as well as basal defences against hemibiotrophic pathogens, systemic immunity is reduced in pepr1 pepr2 plants. Remarkably, PROPEP2/PROPEP3 induction is essentially restricted to the pathogen challenge sites during pathogen-induced systemic immunity. Localized Pep application activates genetically separable jasmonate and salicylate branches in systemic leaves without significant PROPEP2/PROPEP3 induction. Our results suggest that local PEPR activation provides a critical step in connecting local to systemic immunity by reinforcing separate defence signalling pathways.
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