Journal
EMBO JOURNAL
Volume 32, Issue 19, Pages 2535-2547Publisher
WILEY
DOI: 10.1038/emboj.2013.201
Keywords
bone marrow stromal cells; haematopoiesis; haematopoietic stem cells; microenvironment; niches
Categories
Funding
- American Cancer Society [RSG-13-193-01-DDC]
- California Institute for Regenerative Medicine (CIRM) [RN1-00540]
- CIRM Shared Stem Cell Facilities [CL1-00506]
- CIRM Major Facilities [FA1-00617-1]
- CIRM [TG2-01157]
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Haematopoietic stem cell (HSC) niches provide an environment essential for life-long HSC function. Intense investigation of HSC niches both feed off and drive technology development to increase our capability to assay functionally defined cells with high resolution. A major driving force behind the desire to understand the basic biology of HSC niches is the clear implications for clinical therapies. Here, with particular emphasis on cell type-specific deletion of SCL and CXCL12, we focus on unresolved issues on HSC niches, framed around some very recent advances and novel discoveries on the extrinsic regulation of HSC maintenance. We also provide ideas for possible paths forward, some of which are clearly within reach while others will require both novel tools and vision.
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