Journal
EMBO JOURNAL
Volume 31, Issue 6, Pages 1350-1363Publisher
WILEY
DOI: 10.1038/emboj.2011.494
Keywords
axonal transport; dynein; importin; neuronal injury; STAT
Categories
Funding
- Israel Science Foundation [1157/09]
- US-Israel Binational Science Foundation [2003208]
- International Foundation for Research in Paraplegia [P86, P116]
- Dr Miriam and Sheldon G Adelson Medical Research Foundation
- German-Israeli Foundation [1010-168.1/2008]
- Deutsche Forschungsgemeinschaft [KO 1950/3-1]
- NIH [R01-NS041596, K99-NR010797]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [2003208] Funding Source: National Science Foundation
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Retrograde axonal injury signalling stimulates cell body responses in lesioned peripheral neurons. The involvement of importins in retrograde transport suggests that transcription factors (TFs) might be directly involved in axonal injury signalling. Here, we show that multiple TFs are found in axons and associate with dynein in axoplasm from injured nerve. Biochemical and functional validation for one TF family establishes that axonal STAT3 is locally translated and activated upon injury, and is transported retrogradely with dynein and importin alpha 5 to modulate survival of peripheral sensory neurons after injury. Hence, retrograde transport of TFs from axonal lesion sites provides a direct link between axon and nucleus. The EMBO Journal (2012) 31, 1350-1363. doi: 10.1038/emboj. 2011.494; Published online 13 January 2012
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