Journal
EMBO JOURNAL
Volume 31, Issue 11, Pages 2473-2485Publisher
WILEY
DOI: 10.1038/emboj.2012.106
Keywords
intestinal homeostasis; lateral inhibition; neutral competition; population asymmetry; stochastic fate
Categories
Funding
- Wellcome Trust
- EPSRC [EP/032773/1]
- Engineering and Physical Sciences Research Council [EP/F032773/1] Funding Source: researchfish
- Medical Research Council [G0800784, G0800784B] Funding Source: researchfish
- EPSRC [EP/F032773/1] Funding Source: UKRI
- MRC [G0800784] Funding Source: UKRI
Ask authors/readers for more resources
The Drosophila adult posterior midgut has been identified as a powerful system in which to study mechanisms that control intestinal maintenance, in normal conditions as well as during injury or infection. Early work on this system has established a model of tissue turnover based on the asymmetric division of intestinal stem cells. From the quantitative analysis of clonal fate data, we show that tissue turnover involves the neutral competition of symmetrically dividing stem cells. This competition leads to stem-cell loss and replacement, resulting in neutral drift dynamics of the clonal population. As well as providing new insight into the mechanisms regulating tissue self-renewal, these findings establish intriguing parallels with the mammalian system, and confirm Drosophila as a useful model for studying adult intestinal maintenance. The EMBO Journal (2012) 31, 2473-2485. doi: 10.1038/emboj.2012.106; Published online 20 April 2012
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available