Journal
EMBO JOURNAL
Volume 31, Issue 13, Pages 2895-2907Publisher
WILEY
DOI: 10.1038/emboj.2012.129
Keywords
JNK; Mef2; metastasis; Notch; proliferation
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Funding
- American Cancer Society New England Division [PF-10-230-01-DDC]
- NIH [CA 098402]
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Genetic analyses in Drosophila revealed a synergy between Notch and the pleiotropic transcription factor Mef2 (myocyte enhancer factor 2), which profoundly influences proliferation and metastasis. We show that these hyperproliferative and invasive Drosophila phenotypes are attributed to upregulation of eiger, a member of the tumour necrosis factor superfamily of ligands, and the consequent activation of Jun N-terminal kinase signalling, which in turn triggers the expression of the invasive marker MMP1. Expression studies in human breast tumour samples demonstrate correlation between Notch and Mef2 paralogues and support the notion that Notch-MEF2 synergy may be significant for modulating human mammary oncogenesis. The EMBO Journal (2012) 31, 2895-2907. doi: 10.1038/emboj.2012.129; Published online 11 May 2012
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