Journal
EMBO JOURNAL
Volume 32, Issue 1, Pages 60-71Publisher
WILEY
DOI: 10.1038/emboj.2012.326
Keywords
chromatin immunoprecipitation; Drosophila; gene expression; Notch; proliferation
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Funding
- MRC Programme grant [G0800034/1]
- Wellcome Trust [WT083576MA]
- BBSRC
- Cambridge Overseas Trust
- Zdenek Bakala Foundation
- Sackler Foundation
- BBSRC [BB/F00897X/1] Funding Source: UKRI
- MRC [G0800034] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [1103802, BB/F00897X/1] Funding Source: researchfish
- Medical Research Council [G0800034] Funding Source: researchfish
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The outcome of the Notch pathway on proliferation depends on cellular context, being growth promotion in some, including several cancers, and growth inhibition in others. Such disparate outcomes are evident in Drosophila wing discs, where Notch overactivation causes hyperplasia despite having localized inhibitory effects on proliferation. To understand the underlying mechanisms, we have used genomic strategies to identify the Notch-CSL target genes directly activated during wing disc hyperplasia. Among them were genes involved in both autonomous and non-autonomous regulation of proliferation, growth and cell death, providing molecular explanations for many characteristics of Notch induced wing disc hyperplasia previously reported. The Notch targets exhibit different response patterns, which are shaped by both positive and negative feed-forward regulation between the Notch targets themselves. We propose, therefore, that both the characteristics of the direct Notch targets and their cross-regulatory relationships are important in coordinating the pattern of hyperplasia. The EMBO Journal (2013) 32, 60-71. doi:10.1038/emboj.2012.326; Published online 11 December 2012
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