Journal
EMBO JOURNAL
Volume 30, Issue 24, Pages 4931-4941Publisher
WILEY
DOI: 10.1038/emboj.2011.358
Keywords
capsular polysaccharide; LytR-CpsA-Psr proteins; MreB; peptidoglycan; teichoic acids
Categories
Funding
- UK Biotechnology and Biological Sciences Research Council
- BBSRC [BB/G015902/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/G015902/1, 983409] Funding Source: researchfish
Ask authors/readers for more resources
Teichoic acids and acidic capsular polysaccharides are major anionic cell wall polymers (APs) in many bacteria, with various critical cell functions, including maintenance of cell shape and structural integrity, charge and cation homeostasis, and multiple aspects of pathogenesis. We have identified the widespread LytR-Cps2A-Psr (LCP) protein family, of previously unknown function, as novel enzymes required for AP synthesis. Structural and biochemical analysis of several LCP proteins suggest that they carry out the final step of transferring APs from their lipid-linked precursor to cell wall peptidoglycan (PG). In Bacillus subtilis, LCP proteins are found in association with the MreB cytoskeleton, suggesting that MreB proteins coordinate the insertion of the major polymers, PG and AP, into the cell wall. The EMBO Journal (2011) 30, 4931-4941. doi: 10.1038/emboj.2011.358; Published online 30 September 2011
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available