Journal
EMBO JOURNAL
Volume 31, Issue 3, Pages 640-653Publisher
WILEY
DOI: 10.1038/emboj.2011.400
Keywords
D1R; D2R; motor control; motor learning; striatum
Categories
Funding
- FMRE (Belgium)
- FRS-FNRS (Belgium)
- FER from ULB
- Action de Recherche Concertee from the CFWB
Ask authors/readers for more resources
The dorsal striatum is critically involved in a variety of motor behaviours, including regulation of motor activity, motor skill learning and motor response to psychostimulant and neuroleptic drugs, but contribution of D2R-striatopallidal and D1R-striatonigral neurons in the dorsomedial (DMS, associative) and dorsolateral (DLS, sensorimotor) striatum to distinct functions remains elusive. To delineate cell type-specific motor functions of the DMS or the DLS, we selectively ablated D2R- and D1R-expressing striatal neurons with spatial resolution. We found that associative striatum exerts a population-selective control over locomotion and reactivity to novelty, striatopallidal and striatonigral neurons inhibiting and stimulating exploration, respectively. Further, DMS-striatopallidal neurons are involved only in early motor learning whereas gradual motor skill acquisition depends on striatonigral neurons in the sensorimotor striatum. Finally, associative striatum D2R neurons are required for the cataleptic effect of the typical neuroleptic drug haloperidol and for amphetamine motor response sensitization. Altogether, these data provide direct experimental evidence for cell-specific topographic functional organization of the dorsal striatum. The EMBO Journal (2012) 31, 640-653. doi: 10.1038/emboj.2011.400; Published online 8 November 2011
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available