Journal
EMBO JOURNAL
Volume 30, Issue 21, Pages 4345-4355Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/emboj.2011.344
Keywords
enhancers; genome organization; genome topology; transcription
Categories
Funding
- Dutch Scientific Organization (NWO) [91204082, 935170621]
- European Research Council [209700, '4C']
- InteGeR FP7 Marie Curie ITN [PITN-GA-2007-214902]
- European Research Council (ERC) [209700] Funding Source: European Research Council (ERC)
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The non-coding part of our genome contains sequence motifs that can control gene transcription over distance. Here, we discuss functional genomics studies that uncover and characterize these sequences across the mammalian genome. The picture emerging is of a genome being a complex regulatory landscape. We explore the principles that underlie the wiring of regulatory DNA sequences and genes. We argue transcriptional control over distance can be understood when considering action in the context of the folded genome. Genome topology is expected to differ between individual cells, and this may cause variegated expression. High-resolution three-dimensional genome topology maps, ultimately of single cells, are required to understand the cis-regulatory networks that underlie cellular transcriptomes. The EMBO Journal (2011) 30, 4345-4355. doi:10.1038/emboj.2011.344; Published online 27 September 2011
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