Journal
EMBO JOURNAL
Volume 30, Issue 16, Pages 3430-3441Publisher
JOHN WILEY & SONS LTD
DOI: 10.1038/emboj.2011.240
Keywords
A2-type cyclins; differentiation; G2-to-M; proliferation; transcriptional repression
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Funding
- EMBO
- Research Foundation of Flanders
- Ohio State University
- National Science Foundation
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Canada Research Chairs Program
- NSERC
- Agency for Innovation through Science and Technology
- Ghent University [BOF08/01M00408]
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In multicellular organisms, morphogenesis relies on a strict coordination in time and space of cell proliferation and differentiation. In contrast to animals, plant development displays continuous organ formation and adaptive growth responses during their lifespan relying on a tight coordination of cell proliferation. How developmental signals interact with the plant cell-cycle machinery is largely unknown. Here, we characterize plant A2-type cyclins, a small gene family of mitotic cyclins, and show how they contribute to the fine-tuning of local proliferation during plant development. Moreover, the timely repression of CYCA2; 3 expression in newly formed guard cells is shown to require the stomatal transcription factors FOUR LIPS/MYB124 and MYB88, providing a direct link between developmental programming and cell-cycle exit in plants. Thus, transcriptional downregulation of CYCA2s represents a critical mechanism to coordinate proliferation during plant development. The EMBO Journal (2011) 30, 3430-3441. doi:10.1038/emboj.2011.240; Published online 19 July 2011
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