Journal
EMBO JOURNAL
Volume 30, Issue 8, Pages 1420-1421Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/emboj.2011.99
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Recent discoveries of histone demethylases have shown that the dynamic regulation of histone methylation is important in differentiation and development. A paper in this issue of The EMBO Journal demonstrates that an H3K4me3 demethylase, KDM5B, is required for the regulation of self-renewal and pluripotency of embryonic stem (ES) cells by removing intragenic H3K4me3 and repressing cryptic transcription.
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