Journal
EMBO JOURNAL
Volume 30, Issue 2, Pages 263-276Publisher
WILEY
DOI: 10.1038/emboj.2010.314
Keywords
chromatin; condensin; cytokine signalling; epigenetics; quiescence
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Funding
- National Institutes of Health
- American Lebanese Syrian Associated Charities (ALSAC)
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Naive T cells encountering their cognate antigen become activated and acquire the ability to proliferate in response to cytokines. Stat5 is an essential component in this response. We demonstrate that Stat5 cannot access DNA in naive T cells and acquires this ability only after T-cell receptor (TCR) engagement. The transition is not associated with changes in DNA methylation or global histone modification but rather chromatin decondensation. Condensation occurs during thymocyte development and proper condensation is dependent on kleisin-beta of the condensin II complex. Our findings suggest that this unique chromatin condensation, which can affect interpretations of chromatin accessibility assays, is required for proper T-cell development and maintenance of the quiescent state. This mechanism ensures that cytokine driven proliferation can only occur in the context of TCR stimulation. The EMBO Journal (2011) 30, 263-276. doi:10.1038/emboj.2010.314; Published online 17 December 2010
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