Journal
EMBO JOURNAL
Volume 29, Issue 4, Pages 727-739Publisher
WILEY
DOI: 10.1038/emboj.2009.387
Keywords
C. elegans; jmjc-1; microarray; slr-2; stress
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Funding
- NIH [GM066868, INBRE P20RR016474]
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Maintaining a homeostatic interaction with the environment is crucial for the growth, survival, and propagation of all living organisms. Reestablishment of equilibrium after stress is achieved by the activation of complex transcriptional-response networks, many of which remain poorly understood. Here, we report that the zinc-finger protein, SLR-2, is a master stress regulator and is required for the normal response to pleiotropic stress conditions in Caenorhabditis elegans. Using bioinformatical tools, we identified an evolutionarily conserved nucleotide motif present in slr-2 stress-responsive genes and show that this motif is sufficient for stress induction under a variety of conditions. We also demonstrate that JMJC-1, a conserved Jumonji C domain protein, acts downstream of SLR-2 to mediate stress response in C. elegans. Moreover, the role of JMJC-1 in stress response is conserved in Drosophila and mammals. Finally, we provide evidence that the SLR-2-JMJC-1 pathway functions independently of the well-studied DAF-16/FOXO1 network. These findings point to a previously unrecognized phylogenetically conserved master stress-response pathway in metazoa. The EMBO Journal (2010) 29, 727-739. doi: 10.1038/emboj.2009.387; Published online 7 January 2010
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