Journal
EMBO JOURNAL
Volume 29, Issue 21, Pages 3621-3629Publisher
WILEY-BLACKWELL
DOI: 10.1038/emboj.2010.228
Keywords
heat-shock regulation; protein thermosensor; regulated proteolysis; signal transduction
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Funding
- Deutsche Forschungsgemeinschaft (DFG) [HE 1887/8-1]
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Protein quality networks are required for the maintenance of proper protein homeostasis and essential for viability and growth of all living organisms. Hence, regulation and coordination of these networks are critical for survival during stress as well as for virulence of pathogenic species. In low GC, Gram-positive bacteria central protein quality networks are under the control of the global repressor CtsR. Here, we provide evidence that CtsR activity during heat stress is mediated by intrinsic heat sensing through a glycine-rich loop, probably in all Gram-positive species. Moreover, a function for the recently identified arginine kinase McsB is confirmed, however, not for initial inactivation and dissociation of CtsR from the DNA, but for heat-dependent auto-activation of McsB as an adaptor for ClpCP-mediated degradation of CtsR. The EMBO Journal (2010) 29, 3621-3629. doi:10.1038/emboj.2010.228; Published online 17 September 2010
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