Journal
EMBO JOURNAL
Volume 29, Issue 22, Pages 3787-3796Publisher
WILEY
DOI: 10.1038/emboj.2010.254
Keywords
epithelial-mesenchymal transition; O-GlcNAc; OGT; Snail1
Categories
Funding
- Ministry of Education, Science and Technology [R31-2008-000-10086-0, 2010-0018923, 2010-0027736]
- Brain Korea 21 programme
- National R&D Program for Cancer Control, Ministry of Health, Welfare Family Affairs [0720270, A080916]
- Korea Research Institute of Chemical Technology [SI-0905]
- Ministry of Education, Science, and Technology [2009-0067248, 2009-0079653, 2009-0094029, KRF-2008-331-E00328]
- Korea Health Promotion Institute [A080916] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Council of Science & Technology (NST), Republic of Korea [SI-0905] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2009-0079653, 2009-0094029] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Protein O-phosphorylation often occurs reciprocally with O-GlcNAc modification and represents a regulatory principle for proteins. O-phosphorylation of serine by glycogen synthase kinase-3 beta on Snail1, a transcriptional repressor of E-cadherin and a key regulator of the epithelial-mesenchymal transition (EMT) programme, results in its proteasomal degradation. We show that by suppressing O-phosphorylation-mediated degradation, O-GlcNAc at serine112 stabilizes Snail1 and thus increases its repressor function, which in turn attenuates E-cadherin mRNA expression. Hyperglycaemic condition enhances O-GlcNAc modification and initiates EMT by transcriptional suppression of E-cadherin through Snail1. Thus, dynamic reciprocal O-phosphorylation and O-GlcNAc modification of Snail1 constitute a molecular link between cellular glucose metabolism and the control of EMT.
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