Journal
EMBO JOURNAL
Volume 30, Issue 2, Pages 355-363Publisher
WILEY
DOI: 10.1038/emboj.2010.313
Keywords
Arabidopsis; DEL1; endoreduplication; PHR1; UV-B irradiation
Categories
Funding
- Interuniversity Poles of Attraction (IUAP) [VI/33]
- EU [FA0906 UV4]
- European Molecular Biology Organization
Ask authors/readers for more resources
Because of their sessile life style, plants have, evolved the ability to adjust to environmentally harsh conditions. An important aspect of stress adaptation involves the reprogramming of the cell cycle to ensure optimal growth. The atypical E2F transcription factor DP-E2F-like 1 (E2Fe/DEL1) had been found previously to be an important regulator of the endocycle onset. Here, a novel role for E2Fe/DEL1 was identified as a transcriptional repressor of the type-II cyclobutane pyrimidine dimer-photolyase DNA repair gene PHR1. Upon ultraviolet-B (UV-B) treatment, plants knocked out for E2Fe/DEL1 had improved DNA repair abilities when compared with control plants, whereas those overexpressing it performed less well. Better DNA repair allowed E2Fe/DEL1 knockout plants to resume endoreduplication faster than control plants, contributing in this manner to UV-B radiation resistance by compensating the stress-induced reduction in cell number by ploidy-dependent cell growth. As E2Fe/DEL1 levels decreased upon UV-B treatment, we hypothesize that the coordinated transcriptional induction of PHR1 with the endoreduplication onset contributes to the adaptation of plants exposed to UV-B stress. The EMBO Journal (2011) 30, 355-363. doi:10.1038/emboj.2010.313; Published online 3 December 2010
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available