Journal
EMBO JOURNAL
Volume 27, Issue 17, Pages 2271-2280Publisher
WILEY
DOI: 10.1038/emboj.2008.155
Keywords
bacterial pathogenesis; fimbriae; pilus; secretion system
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Funding
- MRC [G0800002] Funding Source: UKRI
- Medical Research Council [G0800002] Funding Source: researchfish
- Medical Research Council [G0800002] Funding Source: Medline
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Bacteria commonly expose non-flagellar proteinaceous appendages on their outer surfaces. These extracellular structures, called pili or fimbriae, are employed in attachment and invasion, biofilm formation, cell motility or protein and DNA transport across membranes. Over the past 15 years, the power of molecular and structural techniques has revolutionalized our understanding of the biogenesis, structure, function and mode of action of these bacterial organelles. Here, we review the five known classes of Gram-negative non-flagellar appendages from a biosynthetic and structural point of view.
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