Journal
EMBO JOURNAL
Volume 27, Issue 2, Pages 315-327Publisher
WILEY
DOI: 10.1038/sj.emboj.7601974
Keywords
endoplasmic reticulum; ER signalling; folding; protein degradation; protein secretion
Categories
Funding
- Telethon [GGP06155] Funding Source: Medline
- Associazione Italiana per la Ricerca sul Cancro Funding Source: Custom
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Eukaryotic cells are able to discriminate between native and non-native polypeptides, selectively transporting the former to their final destinations. Secretory proteins are scrutinized at the endoplasmic reticulum ( ER)-Golgi interface. Recent findings reveal novel features of the underlying molecular mechanisms, with several chaperone networks cooperating in assisting the maturation of complex proteins and being selectively induced to match changing synthetic demands. 'Public' and 'private' chaperones, some of which enriched in specializes subregions, operate for most or selected substrates, respectively. Moreover, sequential checkpoints are distributed along the early secretory pathway, allowing efficiency and fidelity in protein secretion.
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