Journal
EMBO JOURNAL
Volume 27, Issue 21, Pages 2809-2816Publisher
WILEY
DOI: 10.1038/emboj.2008.217
Keywords
disease; ion channels; phosphoinositides; transient receptor potential channels
Categories
Funding
- Interuniversity Attraction Poles Programme - Belgian State - Belgian Science Policy [P6/28]
- Flemish Government (Excellentiefinanciering EF/95/010)
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Transient receptor potential (TRP) cation channels are unique cellular sensors that are involved in multiple cellular functions, ranging from transduction of sensory signals to the regulation of Ca2+ and Mg2+ homoeostasis. Malfunctioning of TRP channels is now recognized as the cause of several hereditary and acquired human diseases. At the time of cloning of the first Drosophila TRP channel, a close connection between gating and phosphatidylinositol phosphates (PIPs) was already recognized. In this review, we summarize current knowledge about the mechanisms of interaction between TRP channels and PIPs, and discuss the possible functional implications of TRP-PIP interactions to human physiology and pathophysiology.
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