Journal
ELECTROPHORESIS
Volume 36, Issue 1, Pages 144-158Publisher
WILEY
DOI: 10.1002/elps.201400368
Keywords
Comprehensive; Coupling; Electromigrative techniques; Heart-cut; Orthogonality
Funding
- Federal Ministry of Education and Research (BMBF) [FKZ 17N1110]
Ask authors/readers for more resources
The analysis of complex samples requires powerful separation techniques. Here, 2D chromatographic separation techniques (e.g. LC-LC, GC-GC) are increasingly applied in many fields. Electrophoretic separation techniques show a different selectivity in comparison to LC and GC and very high separation efficiency. Thus, 2D separation systems containing at least one CE-based separation technique are an interesting alternative featuring potentially a high degree of orthogonality. However, the generally small volumes and strong electrical fields in CE require special coupling techniques. These technical developments are reviewed in this work, discussing benefits and drawbacks of offline and online systems. Emphasis is placed on the design of the systems, their coupling, and the detector used. Moreover, the employment of strategies to improve peak capacity, resolution, or sensitivity is highlighted. Various applications of 2D separations with CE are summarized.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available