Journal
ELECTROPHORESIS
Volume 34, Issue 1, Pages 126-140Publisher
WILEY
DOI: 10.1002/elps.201200344
Keywords
Monolithic columns; Organic-silica hybrid materials; Ring-opening polymerization; Sol-gel
Funding
- National Natural Sciences Foundation of China [20975101, 21175133]
- Creative Research Group Project by NSFC [21021004]
- Hundred Talent Program of Dalian Institute of Chemical Physics of Chinese Academy of Sciences
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Hybrid organic-silica monolithic columns, regarded as a second generation of silica-based monoliths, have received much interest due to their unique properties over the pure silica-based monoliths. This review mainly focuses on development in the fields of preparation of hybrid monolithic columns in a capillary and their application for CEC and capillary liquid chromatography separation, as well as for sample pretreatment of solid-phase microextraction and immobilized enzyme reactor since July 2010. The preparation approaches are comprehensively summarized with three routes: (i) general solgel process using trialkoxysilanes and tetraalkoxysilanes as coprecursors; (ii) one-pot process of alkoxysilanes and organic monomers concomitantly proceeding solgel chemistry and free radical polymerization; and (iii) other polymerization approaches of organic monomers containing silanes. The modification of hybrid monoliths containing reactive groups to acquire the desired surface functionality is also described.
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