Journal
ELECTROPHORESIS
Volume 31, Issue 18, Pages 3014-3027Publisher
WILEY
DOI: 10.1002/elps.201000137
Keywords
Axon guidance; Chemotaxis; Gradient; Microfluidics; Stem cell differentiation
Funding
- Ministry of Education, Science and Technology [R11-2008-044-01002-0]
- Korea Industrial Technology Foundation (KOTEF)
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Concentration gradients play an important role in controlling biological and pathological processes, such as metastasis, embryogenesis, axon guidance, and wound healing. Microfluidic devices fabricated by photo- and soft lithography techniques can manipulate the fluidic flow and diffusion profile to create biomolecular gradients in a temporal and spatial manner. Furthermore, microfluidic devices enable the control of cell-extracellular microenvironment interactions, including cell cell, cell matrix, and cell soluble factor interaction. In this paper, we review the development of microfluidic-based gradient devices and highlight their biological applications.
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