Journal
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
Volume 71, Issue 3, Pages 547-558Publisher
SPRINGER
DOI: 10.1007/s13105-015-0400-5
Keywords
Obesity; Myokine/adipokine; Weight loss; Eicosapentaenoic acid; alpha-Lipoic acid; Fndc5
Categories
Funding
- Ministerio de Economia y Competitividad, Spain [AGL 2009-10873/ALI, BFU2012-36089]
- Instituto de Salud Carlos III (CIBERobn)
- Linea Especial de Investigacion Nutricion, Obesidad y Salud, University of Navarra-Spain
- Asociacion de Amigos de la Universidad de Navarra
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Irisin is a myokine/adipokine with potential role in obesity and diabetes. The objectives of the present study were to analyse the relationship between irisin and glucose metabolism at baseline and during an oral glucose tolerance test (OGTT) and to determine the effects of eicosapentaenoic acid (EPA) and/or alpha-lipoic acid treatment on irisin production in cultured human adipocytes and in vivo in healthy overweight/obese women following a weight loss program. Seventy-three overweight/obese women followed a 30 % energy-restricted diet supplemented without (control) or with EPA (1.3 g/day), alpha-lipoic acid (0.3 g/day) or both EPA + alpha-lipoic acid (1.3 + 0.3 g/day) during 10 weeks. An OGTT was performed at baseline. Moreover, human adipocytes were treated with EPA (100-200 mu M) or alpha-lipoic acid (100-250 mu M) during 24 h. At baseline plasma, irisin circulating levels were positively associated with glucose levels; however, serum irisin concentrations were not affected by the increment in blood glucose or insulin during the OGTT. Treatment with alpha-lipoic acid (250 mu M) upregulated Fndc5 messenger RNA (mRNA) and irisin secretion in cultured adipocytes. In overweight/obese women, irisin circulating levels decreased significantly after weight loss in all groups, while no additional differences were induced by EPA or alpha-lipoic acid supplementation. Moreover, plasma irisin levels were positively associated with higher glucose concentrations at beginning and at endpoint of the study. The data from the OGTT suggest that glucose is not a direct contributing factor of irisin release. The higher irisin levels observed in overweight/obese conditions could be a protective response of organism to early glucose impairments.
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