Journal
ELECTROPHORESIS
Volume 31, Issue 15, Pages 2608-2613Publisher
WILEY
DOI: 10.1002/elps.201000128
Keywords
Amphetamines; Capacitively coupled contactless conductivity detection; CE; Ecstasy; Methamphetamine
Funding
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
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CE with capacitively coupled contactless conductivity detection ((CD)-D-4) was employed for the separation and detection of seven amphetamine analogues as well as amphetamine, dextroamphetamine, methamphetamine and 3,4-methylenedioxymethamphetamine. The separation electrolyte was 30 mM hydroxypropyl-beta-cyclodextrin (HP beta CD) in a 75 mM acetic acid + 25 mM sodium acetate buffer adjusted to pH 4.55. Conductivity detection was compared with UV detection using this same electrolyte. Average detection limits for (CD)-D-4 and UV were 1.3 and 1.0 ppm, respectively. The effects of HP beta CD concentration and BGE composition on the selectivity of the separation were also investigated. An illicit, street-grade sample of 3,4-methylenedioxymethamphetamine (Ecstasy) and a prescription dextroamphetamine tablet were also analysed.
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