Journal
ELECTROPHORESIS
Volume 30, Issue 10, Pages 1684-1691Publisher
WILEY
DOI: 10.1002/elps.200800493
Keywords
Anesthetics; Human plasma; Microdialysis; Microextraction by packed sorbent; NACE-MS
Funding
- Spain's Ministry of Education and Science [2007-60426]
- Research Training Fellowship [BES-2005-10603]
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This paper reports for the first time the use of microextraction by packed sorbent in combination with CE. The combined system was used to determine anesthetic drugs in human plasma. A microdialysis fiber was coupled on-line to the microextraction unit in order to distinguish between free and total concentrations of drugs. The system was automated by connecting the microextraction unit to a syringe pump and interfacing it to a computer. The ensuing method allows the determination of 10 mu g/L concentrations of free drugs and 1 mu g/L concentrations of total drugs from only 200 mu L of sample with an RSD of less than 9%.
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