Journal
ELECTROPHORESIS
Volume 29, Issue 9, Pages 1815-1828Publisher
WILEY
DOI: 10.1002/elps.200700554
Keywords
lab-on-a-chip; microfluidics; miniaturization; optical detection; surface-enhanced; Raman scattering
Funding
- Korea Institute of Industrial Technology(KITECH) [10028350] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [과C6A2605, 2006-02368, R01-2007-000-20238-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Microfluidic chip devices and their application to sensitive chemical and biological analyses have attracted significant attention over the past decade. The miniaturization of reaction systems offers practical advantages over conventional benchtop systems. In this case, however, a highly sensitive on-chip detection method is important for the monitoring of chemical reactions as well as for the detection of analytes inside the channel because the detection volume in a micrometer-size channel is extremely small. Recently, a surface-enhanced Raman scattering (SERS) technique is being regarded as a potential candidate for the highly sensitive detection of analytes in a microfluidic chip. This review provides a general survey and an in-depth look at recent developments in SERS techniques for the biological/environmental analysis of minute analytes in a microfluidic chip.
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