Journal
ELECTRONIC JOURNAL OF BIOTECHNOLOGY
Volume 16, Issue 4, Pages -Publisher
UNIV CATOLICA DE VALPARAISO
DOI: 10.2225/vol16-issue4-fulltext-10
Keywords
gamma-amino butyric acid; functional foods; lactic acid bacteria; medium optimization; response surface methodology
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Funding
- GABA project [05-10-07-380 FR]
- Ministry of Higher Education, Malaysia
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Background: L-glutamic acid, the principal excitatory neurotransmitter in the brain and an important intermediate in metabolism acts as a precursor of gamma-amino butyric acid (GABA). In the present study, culture condition for enhanced glutamic acid production by Lactobacillus plantarum MNZ was optimized and the influence of such conditions on GABA production was evaluated. Results: Results indicated that glutamic acid increased up to 3-fold (3.35) under the following condition: pH 4.5, temperature 37 degrees C, 12% (w/v) glucose and 0.7% (w/v) ammonium nitrate; whilst GABA production was enhanced up to 10-fold under the following condition: pH 4.5, temperature 37 degrees C, 6% (w/v) glucose and 0.7% (w/v) ammonium nitrate. Conclusions: This is the first report for dual biosynthesizing activities of a lactic acid bacterium for the production of glutamic acid and GABA. The results of this study can be further used for developing functional foods rich inglutamic acid and subsequently GABA as a bioactive compound.
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