Journal
ELECTROCHIMICA ACTA
Volume 90, Issue -, Pages 317-325Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.electacta.2012.11.121
Keywords
Levodopa; Serotonin; Carbon ionic liquid electrode; Modified electrode; Electrochemical Sensor
Categories
Funding
- research council of Arak University
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A novel modified carbon ionic liquid electrode is prepared as an electrochemical sensor for simultaneous determination of levodopa (L-dopa) and serotonin (5-HT). The experimental results suggest that a carbon ionic liquid electrode modified with multi-walled carbon nanotubes and cobalt hydroxide nanopartides, and coated with Nafion (Nafion/Co(OH)(2)-MWCNTs/CILE), accelerates the electron transfer reactions of L-dopa and 5-HT. In addition it shows no significant interferences of uric acid and ascorbic acid as electroactive coexistent compounds with L-dopa and 5-HT in biological systems. The fabricated sensor revealed some advantages such as convenient preparation, good stability and high sensitivity toward 5-HT and L-dopa determination. The DPV data showed that the obtained anodic peak currents were linearly dependent on the L-dopa and 5-HT concentrations in the range of 0.25-225 and 0.05-75 mu mol L-1. respectively. The applicability of the modified electrode was demonstrated by simultaneous determination of 5-HT and L-dopa in human serum. (C) 2012 Elsevier Ltd. All rights reserved.
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