Journal
ELECTROCHIMICA ACTA
Volume 97, Issue -, Pages 349-356Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.electacta.2013.02.117
Keywords
PU-Hep NPs; Whole blood; Antibiofouling; Glucose oxidase; Biosensor
Categories
Funding
- NSFC [21144002]
- NSFJS [BK2011781]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Major Program for the Natural Science Fundamental Research of the Higher Education Institutions of Jiangsu Province [12KJA150006]
- Base of production, education & research of prospective joint research project of Jiangsu Province [BY2011109]
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In this paper, the novel polyurethane-heparin nanoparticles (PU-Hep NPs) were synthesized and used to establish an amperometric glucose biosensor that can be applied in whole blood directly, which was based on the antibiofouling property of PU-Hep NPs. More details of preparation of PU-Hep NPs, immobilizing glucose oxidase (GOx) on (PU-Hep)/glass carbon electrode (GCE) and its electrochemical behavior in whole blood were presented. The cyclic voltammetric results indicated that GOx immobilized on the PU-Hep NPs exhibited direct electron transfer reaction, and the cyclic voltammogram (CV) displayed a pair of well-defined and nearly symmetric redox peaks with a formal potential of -408 mV. The biosensor had good electrocatalytic activity toward glucose with a low detection limit 1.4 x 10(-5) M in whole blood. The glucose biosensor did not respond to ascorbic acid (AA) and uric acid (UA) at their concentration normally encountered in blood. The development of materials science will bring a new momentum to electrical analysis. (C) 2013 Elsevier Ltd. All rights reserved.
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