Journal
ELECTROCHEMISTRY COMMUNICATIONS
Volume 33, Issue -, Pages 80-83Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.elecom.2013.04.030
Keywords
MicroRNA; Rolling circle amplification; Quantum dots; Anodic stripping voltammetric
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Funding
- National Basic Research Program of China [2011CB933502]
- National Natural Science Foundation of China [21121091]
- King Saud University [RGP-VPP-029]
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MicroRNA-16 (miR-16) frequently deleted or downregulated in patients with B cell chronic lymphocytic leukemia and thus can be used as promising biomarkers in B-CLL diagnosis and prognosis. Herein, an ultrasensitive miR-16 detection was carried out by combining rolling circle amplification (RCA), quantum dots tagging and anodic stripping voltammetric detection (ASV). The method could specifically quantify miR-16 over a 6-decade dynamic range and reach an ultra-low detection limit of 032 aM. (c). 2013 Elsevier B.V. All rights reserved.
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