Journal
ELECTROCHEMISTRY COMMUNICATIONS
Volume 11, Issue 10, Pages 1956-1959Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.elecom.2009.08.027
Keywords
Electrically controlled drug release; Conducting polymers; Polypyrrole; Fluorescein; Dexamethasone
Categories
Funding
- National Science Foundation [0748001, 0729869]
- National Institute of Health [R01NS062019]
- Department of Defense TATRC [WB1XWH-07-1-0716]
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [0729869] Funding Source: National Science Foundation
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [0748001] Funding Source: National Science Foundation
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An electrically controlled drug release (ECDR) system based on sponge-like nanostructured conducting polymer (CP) polypyrrole (PPy) film was developed. The nanostructured PPy film was composed of template-synthesized nanoporous PPy covered with a thin protective PPy layer. The proposed controlled release system can load drug molecules in the polymer backbones and inside the nanoholes respectively. Electrical stimulation can release drugs from both the polymer backbones and the nanoholes, which significantly improves the drug load and release efficiency. Furthermore, with one drug incorporated in the polymer backbone during electrochemical polymerization, the nanoholes inside the polymer can act as containers to store a different drug, and simultaneous electrically triggered release of different drugs can be realized with this system. (C) 2009 Elsevier B.V. All rights reserved.
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