Prussian blue nanoparticles doped nanocage for controllable immobilization and selective biosensing of enzyme

A conductive nanocage composed of Prussian blue (PB) nanoparticles doped mesocellular silica-carbon foam was prepared. This nanocage possessed ink-bottlelike structure with narrow and controllable pore-size distribution, good biocompatibility and favorable conductivity. The Prussian blue nanoparticles dispersed homogeneously on the mesowalls and provided the nanocage with highly catalytic ability toward the reduction of hydrogen peroxide. The nanocage could be used for volume-selective entrapment of enzyme to prepare a biosensor. The use of the Prussian blue nanoparticles doped nanocage would open new horizons for fabrication of biosensors and biocatalysts. (C) 2007 Elsevier B.V. All rights reserved.