Integrating Ultrathin Polypyrrole Framework on Nickel-Cobalt Layered Double Hydroxide as an Amperometric Sensor for Non-enzymatic Glucose Determination

We prepared a novel amperometric sensor based on nickel cobalt layered double hydroxide (NiCo-LDH) coupling with ultrathin polypyrrole shell (LDH@PPy) for enzyme-free determination of glucose. Using a simple vapor polymerization route, PPy forms an internal conductive framework surrounding the LDH lamellas, leading to improved electronic conductivity as well as mitigated electrochemical impedance. As a consequence, the LDH@PPy sensor endows excellent electrocatalytic performance for glucose determination. High sensitivity (46.04A mM(-1) cm(-2) and 292.84A mM(-1) cm(-2)), wide linear range (5-50M and 0.05-8.2mM), and a low detection limit of 0.80M (S/N=3) could be implemented. The optimization of operation potential, reproducibility, and anti-interference properties of the sensor were also conducted. The LDH@PPy composite presents a promising candidate for rapid and accurate determination of glucose in practical applications.