Journal
ACS NANO
Volume 10, Issue 1, Pages 1565-1571Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.5b07167
Keywords
singlet oxygen; phthalocyanine; ferritin; protein cage; self-assembly; crystal
Categories
Funding
- Emil Aaltonen Foundation
- Academy of Finland [267497, 273645, 263504]
- Academy of Finland through Centres of Excellence Programme
- EU (GLOBASOL) [FP7-ENERGY-2012-J, 309194-2]
- EU (SO2S) [FP7-PEOPLE-2012-ITN, 316975]
- Spanish MINECO [BFU2014-55475R, CTQ-2014-52869-P, CTQ-2014-53673-P]
- Comunidad de Madrid [S2013/MIT-2807]
- Comunidad de Madrid (FOTOCARBON) [S2013/MIT-2841]
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Phthalocyanines (Pc) are non-natural organic dyes with wide and deep impact in materials science, based on their intense absorption at the near-infrared (NIR), longlived fluorescence and high singlet oxygen (O-1(2)) quantum yields. However, Pcs tend to stack in buffer solutions, losing their ability to generate singlet oxygen, which limits their scope of application. Furthermore, Pcs are challenging to organize in crystalline structures. Protein cages, on the other hand, are very promising biological building blocks that can be used to organize different materials into crystalline nanostructures. Here, we combine both kinds of components into photoactive biohybrid crystals. Toward this end, a hierarchical organization process has been designed in which (a) a supramolecular complex is formed between octacationic zinc Pc (1) and a tetraanionic pyrene (2) derivatives, driven by electrostatic and pi-pi interactions, and (b) the resulting tetracationic complex acts as a molecular glue that binds to the outer surface anionic patches of the apoferritin (aFt) protein cage, inducing cocrystallization. The obtained ternary face-centered cubic (fcc) packed cocrystals, with diameters up to 100 mu m, retain the optical properties of the pristine dye molecules, such as fluorescence at 695 nm and efficient light-induced O-1(2) production. Considering that O-1(2) is utilized in important technologies such as photodynamic therapy (PDT), water treatments, diagnostic arrays and as an oxidant in organic synthesis, our results demonstrate a powerful methodology to create functional biohybrid systems with unprecedented long-range order. This approach should greatly aid the development of nanotechnology and biomedicine.
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