Journal
ELECTROANALYSIS
Volume 26, Issue 6, Pages 1224-1235Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/elan.201400055
Keywords
miRNA; Electrochemical detection; Voltammetry; Impedance; Resistive pulse sensing; Concatamer; Peptide nucleic acid
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Funding
- ENIAC (CAJAL4EU)
- Momentum (Lendulet) program of the Hungarian Academy of Sciences [LP2013-63/2013]
- New Szechenyi Plan [TAMOP-4.2.1./B-09/1/KMR-2010-0002]
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The recent progress made in the development of electrochemical methods for microRNA (miRNA) detection is presented. The progress is conceived to be largely due to the invention of novel assay methodologies and the use of various bioreagents and nanostructures. These enable a rigorous control over the sensing inter-face, provide enormous signal amplifications and single-base mismatch specificity. Femtomolar or even subfemtomolar detection limits were shown to be feasible by electrochemical assays. Thus electrochemical detection methodologies are of perspective for diagnostic miRNA detection.
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