Journal
ELECTROANALYSIS
Volume 26, Issue 2, Pages 424-431Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/elan.201300557
Keywords
Amitriptiline; Carbon ionic liquid electrodes; Electrochemistry; Imipramine; Nanoclay
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Funding
- Islamic Azad University, Tehran Science and Research Branch
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A new carbon nanocomposite electrode has been designed by incorporation of montmorillonite nanoclay into a carbon ionic liquid electrode for the electrochemical determination of imipramine (IMP) and amitriptyline (AMT). They are expected to accumulate on the electrode surface through the cooperative interaction of ionic liquid and clay with the drugs. The proposed electrode also possesses attractive electrocatalytic effects towards the drugs especially AMT. Low detection limits of 19nM for IMP and 24nM for AMT were achieved. The proposed nanocomposite electrode exhibits good applicability for monitoring IMP and AMT in pharmaceutical formulations and blood serum samples.
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