Journal
ELECTROANALYSIS
Volume 24, Issue 12, Pages 2291-2301Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/elan.201200426
Keywords
Carbon nanotube paste electrode; Acetaminophen; Ascorbic acid; Surfactant; Multiple response optimization
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Funding
- CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)
- CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)
- UEL (Universidade Estadual de Londrina)
- INCT for Bianalytics (Instituto Nacional de Ciencia e Tecnologia de Bioanalitica)
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A simple procedure for the simultaneous determination of acetaminophen (AC) and ascorbic acid (AA) by differential pulse voltammetry (DPV) using a carbon nanotube paste electrode exploiting measures in cetylpyridinium bromide (CPB) medium is described. Under the best instrumental parameters of DPV, optimized by means of factorial design, the calibration plots in the range 100.0700.0 mu mol?L-1 (r=0.993) and 39.4146.3 mu mol?L-1 (r=0.995) with limits of detection of 7.1 and 2.1 mu mol?L-1, were achieved for AA and AC, respectively. The developed method was successfully applied for the AC and AA determination in pharmaceutical formulations, whose accuracy was attested by comparison with HPLC method.
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