Voltammetric Determination of Trace Antiepileptic Gabapentin with a Silver-Nanoparticle Modified Multiwalled Carbon Nanotube Paste Electrode

For the first time, a novel carbon nanotube bed electrode impregnated with silvernanoparticles (AgNPs) for the determination of trace amounts of gabapentin (GBP) is described. We synthesized the AgNPs via a new procedure. The voltammetric behavior of the electrode was investigated by cyclic voltammetry. There were linear relationships in the ranges from 3.1x10(-9) to 2.9x10(-2) M and from 1.0x10(-8) to 1.0x10(-2) GBP with square wave and differential pulse voltammetric peak currents, respectively. The detection limits were 5.6x10(-10) and 9.7x10(-9) M, respectively. The electrode showed excellent response over a period of 2 months and was successfully applied in human plasma and pharmaceutical capsular products.