Journal
EJSO
Volume 39, Issue 10, Pages 1071-1078Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ejso.2013.07.090
Keywords
Rectal cancer; Chemoradiation; Diffusion-weighted imaging; MRI
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Purpose: To evaluate diffusion-weighted imaging (DWI) for assessment of treatment response in locally advanced rectal cancer (LARC) 8 weeks after neoadjuvant chemoradiotherapy (CRT). Methods and materials: A total of 28 patients with LARC underwent magnetic resonance imaging (MRI) prior to and 8 weeks after CRT. Tumor volume (TV) was calculated on T2-weighted MRI scans as well as the apparent diffusion coefficient (ADC) was calculated using Echo-planar DWI-sequences. All data were correlated to surgical results and histopathologic tumor regression grade (TRG), according to Mandard's classification. Post-treatment difference ADC (%Delta ADC) and TV (%Delta TV) changes at 8 weeks were compared complete response (CR; TRG1) and non-complete response tumors (non-CR; TRG2-5). Results: The mean % ADC increase of CR group was significantly higher compared to non-CR group (77.2 +/- 54.63% vs. 36.0 +/- 29.44%; p = 0.05). Conversely, the mean % TV reduction did not significantly differ in CR group from non-CR group (73.7% vs. 63.77%; p = 0.21). Accordingly, the diagnostic accuracy of the mean % ADC increase to discriminate CR from non-CR group was significantly higher than that of the mean % TV reduction (0.913 vs. 0.658; p = 0.022). No correlation was found between mean % TV reduction and TRG (rho = 0.22; p = 0.3037), whereas a negative correlation between mean % ADC increase and TRG was recorded (r = -0.69; p = 0.006). Conclusion: The mean % ADC increase appears to be a reliable tool to differentiate CR from non-CR after CRT in patients with LARC. (c) 2013 Elsevier Ltd. All rights reserved.
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